Azido-PEG4-hydrazide is a PEG-based linker specifically designed for PROTAC (proteolysis-targeting chimera) synthesis. Functioning as a click chemistry reagent, it features an azide group capable of participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized molecules, making it an essential tool for developing targeted protein degradation strategies in chemical biology research.
Azido-PEG4-hydrazide is a PEG-based linker specifically designed for PROTAC (proteolysis-targeting chimera) synthesis. Functioning as a click chemistry reagent, it features an azide group capable of participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized molecules, making it an essential tool for developing targeted protein degradation strategies in chemical biology research.
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