Fig. 1 · Structure
Documents & Downloads
Azido-PEG7-t-butyl ester
PROTAC Linkers
Azido-PEG7-t-butyl ester is a PEG-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide group that enables efficient click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAC) with alkyne-containing molecules. Additionally, Azido-PEG7-t-butyl ester can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with compounds featuring DBCO or BCN groups, making it a versatile tool in targeted protein degradation research. Its application in the development of PROTACs facilitates the modulation of protein levels, thus advancing studies in cellular biology and therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2596867-40-0 |
| Applications | PROTAC Linkers |
| Formula | C21H41N3O9 |
| Molecular Weight | 479.56 |
| SMILES | O=C(CCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])OC(C)(C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.