Fig. 1 · Structure
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Azido-PEG9-NHS ester
PROTAC Linkers
Azido-PEG9-NHS ester is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. Characterized by its azide functional group, this compound facilitates click chemistry reactions, specifically copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkynyl-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds, making it a versatile reagent for chemical biology applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2801772-87-0 |
| Applications | PROTAC Linkers |
| Formula | C25H44N4O13 |
| Molecular Weight | 608.64 |
| SMILES | O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.