Fig. 1 · Structure
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β-Anhydroicaritin
TNF Receptor Inhibitor
β-Anhydroicaritin is a TNF receptor inhibitor derived from Boswellia carterii. This compound exhibits significant biological activities, including anti-osteoporosis effects, estrogen regulation, and antitumor properties. It has been shown to improve periodontal tissue degradation and inhibit the synthesis and secretion of pro-inflammatory cytokines such as TNF-α and MMP-3 in diabetic rat models. Additionally, β-Anhydroicaritin decreases the production of inflammatory mediators like NO, IL-10, MCP-1, and IL-6 in peritonitis mice, while also reducing intracellular calcium levels and iNOS protein expression.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 38226-86-7 |
| Applications | TNF Receptor Inhibitor |
| Formula | C21H20O6 |
| Molecular Weight | 368.38 |
| Synonyms | Cycloicaritin |
| SMILES | O=C1C2=C(O)C=C3C(CCC(C)(C)O3)=C2OC(C4=CC=C(OC)C=C4)=C1O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.