Fig. 1 · Structure
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B4148
Bradykinin Receptor Antagonist
B4148 is a selective competitive antagonist of the bradykinin receptor, effectively blocking the action of bradykinin. This compound has been shown to significantly inhibit bradykinin-induced hypotension in rat models, particularly in the context of endotoxin shock induced by Escherichia coli lipopolysaccharide. Researchers can utilize B4148 to study vascular responses and blood pressure regulation under inflammatory conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 103412-37-9 |
| Applications | Bradykinin Receptor Antagonist |
| Formula | C62H95N19O14S2 |
| Molecular Weight | 1394.67 |
| SMILES | C(=O)([C@H]1N(C([C@@H](NC([C@@H](NC([C@H](CCCCN)N)=O)CCCCN)=O)CCCNC(=N)N)=O)C[C@H](O)C1)N2[C@H](C(NCC(N[C@@H](CC3=CC=CS3)C(N[C@H](C(N[C@H](CC4=CC=CC=C4)C(N[C@@H](CC5=CC=CS5)C(N[C@@H](CCCNC(=N)N)C(O)=O)=O)=O)=O)CO)=O)=O)=O)CCC2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.