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BACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.69 mL | 128.43 mL | 256.85 mL |
| 0.5 mM | 5.14 mL | 25.69 mL | 51.37 mL |
| 1 mM | 2.57 mL | 12.84 mL | 25.69 mL |
| 5 mM | 0.51 mL | 2.57 mL | 5.14 mL |
*The above data is based on the productmolecular weight 389.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12183 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1310347-50-2 |
| Formula | C18H14F3N5O2 |
| M. Wt | 389.33 |
| Solubility | DMSO |
| Purity | >98% |
| SMILES | O=C(C1=NC=C(C#N)C=C1)NC2=CC=C(F)C([[email protected]@]3(C)N=C(N)OCC3(F)F)=C2 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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