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BACE1-IN-9

BACE1 Inhibitor

BACE1-IN-9 is a potent inhibitor of β-site APP cleaving enzyme 1 (BACE1), exhibiting an IC50 of 1.2 µM. This compound is significant in the context of Alzheimer's disease research, as it inhibits the cleavage of amyloid precursor protein, thereby potentially reducing amyloid beta production. BACE1-IN-9 can be utilized in studies aimed at elucidating the role of BACE1 in neurodegeneration and assessing therapeutic approaches for Alzheimer's disease.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2872604-91-4
Applications	BACE1 Inhibitor
Formula	C₃₀H₄₅N₅O₉
Molecular Weight	619.71
SMILES	CCC[C@@H]1NC([C@H](C(C)(OC/C=C\C[C@H](NC1=O)[C@@H](CNC2=CC=C(C=C2)CC(O)=O)O)C)NC([C@H](CCC(O)=O)N)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.