Fig. 1 · Structure
Documents & Downloads
Balinatunfib
TNFR1 Inhibitor
Balinatunfib is an orally active inhibitor of TNF receptor 1 (TNFR1) signaling. It functions by binding to the central pocket of the soluble TNFα trimer, stabilizing an asymmetric conformation that prevents TNFα from associating with TNFR1, while sparing TNFR2. This inhibition results in a reduction of inflammatory pathways, making Balinatunfib useful for investigating mechanisms of autoimmune diseases and exploring potential therapeutic interventions.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2248726-53-4 |
| Applications | TNFR1 Inhibitor |
| Formula | C27H24F2N6O2 |
| Molecular Weight | 502.52 |
| Synonyms | SAR-441566; TNFα activity modulator 3 |
| SMILES | FC(F)OC1=C(C(C2=O)=CC=C1)[C@](C[C@@]3([H])N2C)([H])N4C3=NC5=CC=C(C6=CN=C(C7(CCC7)N)N=C6)C=C45 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.