Fig. 1 · Structure

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BAR501

GPBAR1 agonist

BAR501 is a potent and selective agonist of GPBAR1 with an EC50 of 1 μM.

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
HEK293 EC50 1.03 μM Agonist activity at GP-BAR1 (unknown origin) in human HEK293 cells assessed as receptor transactivation at 100 nM to 50 uM incubated for 16 hrs by CRE-driven luciferase reporter gene assay [PMID: 25247751]

Specifications

Manufacturer Adooq Bioscience
Actions Agonist
CAS Number 1632118-69-4
Applications GPBAR1 agonist
Formula C26H46O3
Molecular Weight 406.64
SMILES
C[C@H](CCCO)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@@H](O)[C@@H](CC)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C

Storage & Solubility

In Vitro Solubility

Reported Solubility

SolventReported Solubility
DMSO 79 mg/mL (194.27 mM)
Water Insoluble
Ethanol 79 mg/mL

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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