Fig. 1 · Structure
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BAY 73-1449
Prostacyclin Receptor Antagonist
BAY 73-1449 is a highly potent and selective antagonist of the prostacyclin receptor (IP), demonstrating an IC50 of less than 0.1 nM in cAMP assays using human HEL cells and rat dorsal root ganglion (DRG) neurons. This compound serves as a valuable tool in research aimed at elucidating the role of prostacyclin signaling in cardiovascular physiology, particularly in studies focused on blood pressure regulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 693790-96-4 |
| Applications | Prostacyclin Receptor Antagonist |
| Formula | C26H23N3O3 |
| Molecular Weight | 425.48 |
| SMILES | O=C(O)[C@@H](CC1=CC=CC=C1)NC2=NC=NC(C3=CC=C(OCC4=CC=CC=C4)C=C3)=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.