BAY 73-1449 is a highly potent and selective antagonist of the prostacyclin receptor (IP), demonstrating an IC50 of less than 0.1 nM in cAMP assays using human HEL cells and rat dorsal root ganglion (DRG) neurons. This compound serves as a valuable tool in research aimed at elucidating the role of prostacyclin signaling in cardiovascular physiology, particularly in studies focused on blood pressure regulation.
BAY 73-1449 is a highly potent and selective antagonist of the prostacyclin receptor (IP), demonstrating an IC50 of less than 0.1 nM in cAMP assays using human HEL cells and rat dorsal root ganglion (DRG) neurons. This compound serves as a valuable tool in research aimed at elucidating the role of prostacyclin signaling in cardiovascular physiology, particularly in studies focused on blood pressure regulation.
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