Fig. 1 · Structure
Documents & Downloads
BAY-7598
MMP12 Inhibitor
BAY-7598 is a selective inhibitor of matrix metalloproteinase 12 (MMP12), demonstrating potent activity with IC50 values of 0.085 nM for human MMP12, 0.67 nM for murine MMP12, and 1.1 nM for rat MMP12. This orally bioavailable compound is valuable for research applications involving chronic inflammatory diseases, where MMP12 plays a critical role in tissue remodeling and inflammation. Its specificity for MMP12 allows for targeted studies in the mechanistic understanding of these conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1816257-74-5 |
| Applications | MMP12 Inhibitor |
| Formula | C28H31N3O6 |
| Molecular Weight | 505.56 |
| SMILES | O=C([C@H]1[C@H](CN2N=NC3=CC=CC=C3C2=O)CC[C@@H]1C(C4=CC=C(OCCC5CCOCC5)C=C4)=O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.