BD-Oligo is an oligomer-specific fluorescent chemical probe that selectively targets Aβ oligomer assemblies, distinguishing them from monomers and fibrils. Utilizing diversity-directed fluorescent library screening and advanced computational techniques, BD-Oligo enables real-time monitoring of oligomer formation during Aβ peptide fibrillogenesis. Additionally, this probe demonstrates blood-brain barrier permeability, allowing for in vivo staining of Aβ oligomers, making it a valuable tool for studying Alzheimer's disease and related neurodegenerative processes.
BD-Oligo is an oligomer-specific fluorescent chemical probe that selectively targets Aβ oligomer assemblies, distinguishing them from monomers and fibrils. Utilizing diversity-directed fluorescent library screening and advanced computational techniques, BD-Oligo enables real-time monitoring of oligomer formation during Aβ peptide fibrillogenesis. Additionally, this probe demonstrates blood-brain barrier permeability, allowing for in vivo staining of Aβ oligomers, making it a valuable tool for studying Alzheimer's disease and related neurodegenerative processes.
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