Fig. 1 · Structure
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Beclabuvir hydrochloride
HCV Inhibitor
Beclabuvir hydrochloride is an allosteric inhibitor targeting the thumb site 1 of hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. This compound effectively inhibits recombinant NS5B proteins across HCV genotypes 1, 3, 4, and 5 with an IC50 of less than 28 nM. Its application in research includes studying antiviral mechanisms and developing therapies against HCV, making it a critical tool for investigations into hepatitis C treatments.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 958002-36-3 |
| Applications | HCV Inhibitor |
| Formula | C36H46ClN5O5S |
| Molecular Weight | 696.30 |
| Synonyms | BMS-791325 (hydrochloride) |
| SMILES | O=C(N1C2CCC1CN(C)C2)[C@@]3(CN4C5=C(C6CCCCC6)C7=CC=C(C(NS(=O)(N(C)C)=O)=O)C=C47)[C@H](C8=CC(OC)=CC=C85)C3.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.