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Benzyl-PEG3-methyl ester

PROTAC Linker

Benzyl-PEG3-methyl ester is a polyethylene glycol (PEG)-based linker used in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the effective conjugation of target ligands to E3 ligase moieties, enabling selective protein degradation. Its unique structure promotes solubility and stability, making it suitable for various chemical biology applications, including targeted protein modulation and therapeutic discovery.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	127457-61-8
Applications	PROTAC Linker
Formula	C₁₅H₂₂O₅
Molecular Weight	282.33
SMILES	O=C(OC)CCOCCOCCOCC1=CC=CC=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.