BET-IN-12 is an orally active inhibitor of bromodomain and extra-terminal (BET) proteins, specifically targeting BRD4 with an IC50 of 0.9 nM. This compound demonstrates significant ability to disrupt BET protein interactions with acetylated lysines, thereby influencing gene expression and cellular signaling pathways. BET-IN-12 is utilized in research exploring therapeutic strategies for various cancers and inflammatory diseases, making it a valuable tool for studying the role of BET proteins in these conditions.
BET-IN-12 is an orally active inhibitor of bromodomain and extra-terminal (BET) proteins, specifically targeting BRD4 with an IC50 of 0.9 nM. This compound demonstrates significant ability to disrupt BET protein interactions with acetylated lysines, thereby influencing gene expression and cellular signaling pathways. BET-IN-12 is utilized in research exploring therapeutic strategies for various cancers and inflammatory diseases, making it a valuable tool for studying the role of BET proteins in these conditions.
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