BET-IN-19

Name: BET-IN-19
Brand: Adooq Bioscience
SKU: A24430
Rating: 5 (288 reviews)

Catalog No.: A24430

BET inhibitor

BET-IN-19 (Compound 146) is a BET inhibitor that suppresses hIL-6 mRNA transcription and c-Myc activity in human AML MV4-11 cells, with IC₅₀ values of ≤0.3 μM. It also inhibits the binding of tetra-acetylated histone H4 to BRD4 bromodomain 1 with an IC₅₀ of ≤0.3 μM.

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Grouped product items
Size	Price	Stock
5mg	$144.00	In stock
10mg	$248.00	In stock
50mg	$736.00	In stock
100mg	$1,440.00	In stock
Bulk Size	Bulk Discount

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Biological Activity

Description	BET-IN-19 (Compound 146) is a BET inhibitor that suppresses hIL-6 mRNA transcription and c-Myc activity in human AML MV4-11 cells, with IC₅₀ values of ≤0.3 μM. It also inhibits the binding of tetra-acetylated histone H4 to BRD4 bromodomain 1 with an IC₅₀ of ≤0.3 μM.

Product Information

Catalog Num	A24430
Formula	C19H19N5O
Molecular Weight	333.39
CAS Number	1643947-30-1
SMILES	CNC1=NC(N=CC(C2=C(C)ON=C2C)=C3)=C3N1CC4=CC=CC=C4
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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