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BET-IN-21

Catalog No.: A40460
BET Inhibitor
BET-IN-21 is a selective BET inhibitor targeting the extra terminal domain, demonstrating a Ki of 230 nM. This compound effectively inhibits microglial activation and exhibits therapeutic benefits in models of experimental autoimmune encephalomyelitis. It serves as a valuable tool for research into neuroinflammation and related neurodegenerative disorders.
BET-IN-21 3014815-06-3 BET Inhibitor
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionBET-IN-21 is a selective BET inhibitor targeting the extra terminal domain, demonstrating a Ki of 230 nM. This compound effectively inhibits microglial activation and exhibits therapeutic benefits in models of experimental autoimmune encephalomyelitis. It serves as a valuable tool for research into neuroinflammation and related neurodegenerative disorders.
Product Information
Catalog NumA40460
FormulaC20H20N6
Molecular Weight344.41
CAS Number3014815-06-3
SMILESCC1=NN(C(C)=C1C2=CC(C3=C4NC=NC4=NC=C3)=CN=C2)CC5CC5
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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