LGF308 is a selective PROTAC degrader targeting BRD4, designed to promote the degradation of BRD4 through the formation of a ternary complex with DCAF11. This compound demonstrates potent cytotoxicity in cancer cells while sparing normal cells, effectively inducing apoptosis by upregulating apoptosis-related proteins. Additionally, LGF308 significantly inhibits tumor cell proliferation and migration in breast cancer and triple-negative breast cancer cell lines, making it a valuable tool for research in breast cancer biology.
LGF308 is a selective PROTAC degrader targeting BRD4, designed to promote the degradation of BRD4 through the formation of a ternary complex with DCAF11. This compound demonstrates potent cytotoxicity in cancer cells while sparing normal cells, effectively inducing apoptosis by upregulating apoptosis-related proteins. Additionally, LGF308 significantly inhibits tumor cell proliferation and migration in breast cancer and triple-negative breast cancer cell lines, making it a valuable tool for research in breast cancer biology.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
