BG11 is a potent ferroptosis inducer that promotes the accumulation of Fe2+ ions and intracellular lipid peroxides, leading to ferroptotic cell death. It modulates the expression of apoptotic regulators such as Bax and Bcl-2, facilitating apoptosis in MDA-MB-231 breast cancer cells. Furthermore, BG11 causes G0/G1 and S phase cell cycle arrest, significantly inhibiting the proliferation, migration, and invasion of triple-negative breast cancer (TNBC) cells, with IC50 values of 0.49 μM for MDA-MB-231 and 0.52 μM for BT549. In preclinical mouse models, BG11 demonstrates notable antitumor efficacy.
BG11 is a potent ferroptosis inducer that promotes the accumulation of Fe2+ ions and intracellular lipid peroxides, leading to ferroptotic cell death. It modulates the expression of apoptotic regulators such as Bax and Bcl-2, facilitating apoptosis in MDA-MB-231 breast cancer cells. Furthermore, BG11 causes G0/G1 and S phase cell cycle arrest, significantly inhibiting the proliferation, migration, and invasion of triple-negative breast cancer (TNBC) cells, with IC50 values of 0.49 μM for MDA-MB-231 and 0.52 μM for BT549. In preclinical mouse models, BG11 demonstrates notable antitumor efficacy.
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