Fig. 1 · Structure
Documents & Downloads
BI-2545
ATX Inhibitor
BI-2545 is a selective autotaxin (ATX) inhibitor that demonstrates potent activity in reducing lysophosphatidic acid (LPA) levels, with IC50 values of 2.2 nM for human ATX and 3.4 nM for rat ATX. This compound serves as a valuable tool for exploring ATX's role in various biological processes, including inflammation and cancer progression. Its application in research can provide insights into the therapeutic potential of targeting autotaxin in relevant disease models.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2162961-71-7 |
| Applications | ATX Inhibitor |
| Formula | C23H19F6N5O3 |
| Molecular Weight | 527.42 |
| SMILES | O=C(N1C[C@]2([H])[C@H](CNC(C3=CC=C(NN=N4)C4=C3)=O)[C@]2([H])C1)OCC5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.