BI-2865 is a non-covalent pan-KRAS inhibitor that binds to wild-type and mutant KRAS variants, including G12C, G12D, G12V, and G13D, with dissociation constants (K\_D) of 6.9, 4.5, 32, 26, and 4.3 nM, respectively. It inhibits the proliferation of Ba/F3 cells expressing KRAS^G12C, KRAS^G12D, or KRAS^G12V, with a mean IC₅₀ of approximately 140 nM.
BI-2865 is a non-covalent pan-KRAS inhibitor that binds to wild-type and mutant KRAS variants, including G12C, G12D, G12V, and G13D, with dissociation constants (K\_D) of 6.9, 4.5, 32, 26, and 4.3 nM, respectively. It inhibits the proliferation of Ba/F3 cells expressing KRAS^G12C, KRAS^G12D, or KRAS^G12V, with a mean IC₅₀ of approximately 140 nM.
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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