Fig. 1 · Structure
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BI-4394
MMP-13 Inhibitor
BI-4394 is a potent and selective inhibitor of matrix metalloproteinase-13 (MMP-13), with an IC50 of 1 nM. This orally bioavailable compound exhibits greater than 1000-fold selectivity over other MMPs, making it a valuable tool for investigating the role of MMP-13 in osteoarthritis and related conditions. Its activity offers potential applications in the study of cartilage degradation and therapeutic approaches targeting this specific pathway.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1222173-37-6 |
| Applications | MMP-13 Inhibitor |
| Formula | C24H22N4O5 |
| Molecular Weight | 446.46 |
| Synonyms | MMP13-IN-3 |
| SMILES | O=C(C(N1)=CC2=C1C=CC(C3=CC(C(NCC4=CC=C(C(O)=O)C=C4)=O)=NN3C)=C2)OCC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.