Fig. 1 · Structure
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BI-9627 hydrochloride
NHE1 Inhibitor
BI-9627 hydrochloride is a selective inhibitor of sodium-hydrogen exchanger isoform 1 (NHE1), exhibiting an IC50 of 6 and 31 nM in intracellular pH recovery and human platelet swelling assays, respectively. This compound demonstrates over 30-fold selectivity against NHE2 and negligible activity against NHE3 isoforms. BI-9627 hydrochloride effectively decreases autophagy in HTR-8/SVneo cells and can significantly lower the pH of human sperm, counteracting the effects of DMA. It further prolongs calcium recovery time in knockout hiPSC-derived cardiomyocytes and exhibits favorable pharmacokinetic properties along with low potential for drug-drug interactions, showcasing potent efficacy in models of ischemia-reperfusion injury.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1422252-46-7 |
| Applications | NHE1 Inhibitor |
| Formula | C16H20ClF3N4O2 |
| Molecular Weight | 392.80 |
| SMILES | NC(NC(C1=CC=C(C2CCN(C(C)=O)CC2)C(C(F)(F)F)=C1)=O)=N.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.