Fig. 1 · Structure
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BIIB 513
NHE 1 Inhibitor
BIIB 513 is a selective inhibitor of sodium-hydrogen exchanger 1 (NHE 1), targeting its role in cardiac protection during myocardial ischemia. It effectively inhibits acid load recovery with an IC50 of 27 nmol/L in cells expressing wild-type NHE 1 under conditions of acute acid load, making it a valuable tool for studying cardiac physiology and potential therapeutic strategies in ischemic heart disease.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 265986-98-9 |
| Applications | NHE 1 Inhibitor |
| Formula | C19H25N5O8S2 |
| Molecular Weight | 515.56 |
| SMILES | O=C(NC(N)=N)C1=CC=C(N2CCN(C(C3=CC=CO3)=O)CC2)C(S(=O)(C)=O)=C1.CS(=O)(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.