BIIE-0246 dihydrochloride

Catalog No.: A62246
NPY Receptor Antagonist
BIIE-0246 dihydrochloride is a potent and highly selective non-peptide antagonist of the neuropeptide Y (NPY) Y2 receptor, exhibiting an IC50 value of 15 nM. This compound effectively inhibits NPY signaling, making it valuable for research on appetite regulation, neuroprotection, and anxiety-related disorders. BIIE-0246 dihydrochloride provides a robust tool for investigating the physiological roles of NPY and its involvement in various pathophysiological conditions.
Grouped product items
Size Price Stock Qty
1mg
$605.00
In stock
10mg
$1,335.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionBIIE-0246 dihydrochloride is a potent and highly selective non-peptide antagonist of the neuropeptide Y (NPY) Y2 receptor, exhibiting an IC50 value of 15 nM. This compound effectively inhibits NPY signaling, making it valuable for research on appetite regulation, neuroprotection, and anxiety-related disorders. BIIE-0246 dihydrochloride provides a robust tool for investigating the physiological roles of NPY and its involvement in various pathophysiological conditions.
Product Information
Catalog NumA62246
FormulaC49H59Cl2N11O6
Molecular Weight968.97
CAS Number246146-31-6
SMILESO=C1C2=CC=CC=C2C(N3CCN(CC3)C(CC4(CCCC4)CC(N[C@@H](CCCNC(N)=N)C(NCCN5C(N(C6=CC=CC=C6)N(C7=CC=CC=C7)C5=O)=O)=O)=O)=O)C8=CC=CC=C8N1.Cl.Cl
SynonymsAR-H 053591 dihydrochloride
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