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Gene Editing & Transfection Enhancers

Gene editing and transfection enhancers are additives that improve gene delivery and the outcome of genome editing. After a Cas9-induced double-strand break, inhibitors of DNA-dependent protein kinase (DNA-PK) such as AZD7648, NU7441 and nedisertib favor homology-directed repair (HDR). SCR7 is reported to inhibit DNA ligase IV, while RS-1 stimulates the RAD51 recombinase. Cationic polymers such as hexadimethrine bromide and protamine sulfate increase the efficiency of viral transduction. Chloroquine is added during calcium phosphate transfection and lentivirus production to reduce lysosomal degradation of plasmid DNA.

Cat. No.

A16445

CAS No.

50-63-5

Chloroquine Phosphate

Chloroquine phosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator.

In stock View Details

100 mg

$35.00

250 mg

$50.00

All 3 sizes
Cat. No.

A48126

CAS No.

9012-00-4

Protamine from salmon

Protamine from salmon is a biochemical assay reagent that serves as an antagonist to heparin, effectively neutralizing its anticoagulant effects. This compound exhibits antioxidant and antimicrobial properties, making it valuable in various research applications. It is particularly useful in studies involving antithrombin complexes, especially in canine samples pretreated with heparin in vitro.

In stock View Details

5 mg

$20.00

10 mg

$30.00

All 3 sizes

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