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Stem Cell Reprogramming & Differentiation

Stem cell reprogramming and differentiation reagents are small molecules that steer cell identity in culture. Chemical cocktails can replace or support transcription factors when somatic cells are reprogrammed into induced pluripotent stem cells (iPSCs). Frequent components include the histone deacetylase (HDAC) inhibitor valproic acid and the lysine-specific demethylase 1 (LSD1) inhibitor tranylcypromine. RepSox blocks the transforming growth factor beta (TGF-β) type I receptor and can replace the transcription factor Sox2. Inhibition of glycogen synthase kinase 3 (GSK-3) with CHIR-99021 and of MAP kinase kinase (MEK) with PD0325901 keeps mouse embryonic stem cells in the ground state. Differentiation protocols use retinoic acid, the Hedgehog pathway agonists SAG and purmorphamine, and IDE1 for definitive endoderm.

6 Items

  • IDE1
    Cat. No.
    A12469
    CAS No.
    1160927-48-9

    IDE1

    IDE1 is a potent cell-permeable definitive endoderm formation inducer (EC50 = 125 nM, ESC) similar to IDE 2.

    In stock View Details
    1 mg
    $35.00
    2 mg
    $55.00
    All 8 sizes
  • Cardiogenol C
    Cat. No.
    A15773
    CAS No.
    671225-39-1

    Cardiogenol C

    Cardiogenol C is a potent and cell permeable inducer of embryonic stem cell differentiation in cardiomyocytes displaying an Ec50 of 100nm.

    In stock View Details
    1 mg
    $30.00
    5 mg
    $75.00
    All 7 sizes
  • ISX-9
    Cat. No.
    A15774
    CAS No.
    832115-62-5

    ISX-9

    Synonyms: Isoxazole 9

    ISX-9 is a small molecule inducer of adult neural stem cell differentiation.

    In stock View Details
    2 mg
    $35.00
    5 mg
    $60.00
    All 8 sizes
  • O4I2
    Cat. No.
    A16091
    CAS No.
    165682-93-9

    O4I2

    O4I2 is a potent inducers of Oct3/4. O4I2 showed high activity in enforcing Oct3/4 expression. O4I2 is a new class of small molecules suitable for iPSC generation.

    In stock View Details
    5 mg
    $25.00
    10 mg
    $30.00
    All 7 sizes
  • Neurodazine
    Cat. No.
    A24870
    CAS No.
    937807-66-4

    Neurodazine

    Neurodazine is a neurogenesis inducer that promotes the differentiation of pluripotent cells into neuronal lineages. This compound activates the Wnt and Shh signaling pathways, facilitating neural development and potentially improving neuroregeneration applications. Neurodazine is suitable for research in developmental biology, neuroscience, and regenerative medicine.

    In stock View Details
    2 mg
    $45.00
    5 mg
    $65.00
    All 6 sizes
  • Oct4 inducer-2
    Cat. No.
    A84791
    CAS No.
    1494691-70-1

    Oct4 inducer-2

    Oct4 inducer-2 is a compound that promotes the expression of endogenous OCT4, facilitating the maintenance and proliferation of human induced pluripotent stem cells (hiPSCs). This inducer is valuable for research applications focused on stem cell biology, regenerative medicine, and anti-aging studies. By enhancing OCT4 levels, Oct4 inducer-2 supports the maintenance of pluripotency, making it an essential tool for scientists investigating cellular reprogramming and differentiation.

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    Out of stock

    All 3 sizes

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