Stem Cell Reprogramming & Differentiation

Cat. No.

A34556

CAS No.

2319939-07-4

RepSox hydrochloride

Synonyms: E-616452 hydrochloride; SJN 2511 hydrochloride

RepSox hydrochloride is a highly selective inhibitor of transforming growth factor-β receptor I (TGF-β-RI) and activin-like kinase 5 (ALK5). It effectively inhibits ALK5 autophosphorylation with an IC50 value of 4 nM. This reagent is valuable for investigating the roles of TGF-β signaling in obesity and metabolic disorders, including type 2 diabetes.

Cat. No.

A37094

CAS No.

2109414-84-6

Laduviglusib dihydrochloride

Synonyms: CHIR-99021 dihydrochloride; CT99021 dihydrochloride

Laduviglusib dihydrochloride is a selective inhibitor of glycogen synthase kinase-3 (GSK-3), an enzyme involved in numerous cellular processes including glycogen synthesis, cell differentiation, and apoptosis. By inhibiting GSK-3, Laduviglusib dihydrochloride promotes cell survival and has been extensively studied in the context of neurodegenerative diseases, diabetes, and cancer research. This compound serves as a valuable tool for elucidating the role of GSK-3 in various signaling pathways and therapeutic applications.

Cat. No.

A57088

CAS No.

56563-17-8

PluriSIn #2

PluriSIn #2 is a selective transcriptional inhibitor of topoisomerase II α (TOP2A). This compound effectively eliminates undifferentiated human pluripotent stem cells (hPSCs), making it a valuable tool for stem cell research and differentiation studies. Its ability to precisely target TOP2A provides researchers with a means to manipulate pluripotency and investigate cellular differentiation processes.

Cat. No.

A68724

CAS No.

864716-85-8

Mesendogen

Mesendogen is a selective TRPM6 inhibitor that plays a crucial role in the regulation of magnesium homeostasis. It enhances the differentiation of human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) into mesodermal and definitive endoderm lineages. This compound is valuable for research focused on early embryonic development and the role of magnesium in cellular processes.

Cat. No.

A79138

CAS No.

155-09-9

Tranylcypromine

Synonyms: SKF 385

Tranylcypromine is a potent monoamine oxidase (MAO) inhibitor that increases levels of neurotransmitters such as serotonin, norepinephrine, and dopamine in the brain. This compound is primarily used in the research of mood disorders and depression therapies, offering insights into the biochemical pathways involved in these conditions. Its specific mechanism of action makes it valuable for studying the modulation of neurotransmitter systems and the pharmacological effects of MAO inhibition.