Biotin-PEG2-azide is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs through its primary mechanism of action involving click chemistry. It features an azide group capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, Biotin-PEG2-azide can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. This dual reactivity makes it a valuable tool for targeted protein degradation research and other applications in chemical biology.
Biotin-PEG2-azide is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs through its primary mechanism of action involving click chemistry. It features an azide group capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, Biotin-PEG2-azide can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. This dual reactivity makes it a valuable tool for targeted protein degradation research and other applications in chemical biology.
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