Bis-SS-C3-sulfo-NHS ester

Catalog No.: A43252
ADC Linker
Bis-SS-C3-sulfo-NHS ester is a cleavable linker designed for the development of antibody-drug conjugates (ADCs). This compound is pivotal in facilitating selective drug delivery by connecting cytotoxic agents to antibodies via a disulfide bond, ensuring targeted release within the tumor microenvironment. It is widely applied in research focused on ADC formulation and optimization strategies in cancer therapeutics.
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5mg
10mg
50mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionBis-SS-C3-sulfo-NHS ester is a cleavable linker designed for the development of antibody-drug conjugates (ADCs). This compound is pivotal in facilitating selective drug delivery by connecting cytotoxic agents to antibodies via a disulfide bond, ensuring targeted release within the tumor microenvironment. It is widely applied in research focused on ADC formulation and optimization strategies in cancer therapeutics.
Product Information
Catalog NumA43252
FormulaC16H20N2O14S4
Molecular Weight592.60
CAS Number98604-89-8
SMILESO=S(C(C1)C(N(OC(CCCSSCCCC(ON2C(C(S(=O)(O)=O)CC2=O)=O)=O)=O)C1=O)=O)(O)=O
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