Bis-sulfone-PEG8-NHS ester is a bis-alkylating labeling reagent that selectively targets cysteine sulfur atoms from native disulfides. It facilitates bis-alkylation by conjugating thiols derived from the two cysteine residues of a reduced native disulfide bond, such as those present in interchain disulfide bonds of antibodies. This reaction covalently rebridges disulfide bonds via a three-carbon bridge, preserving protein structure. The hydrophilic PEG spacer enhances solubility in aqueous solutions, making it suitable for various biochemical assays and labeling applications.
Bis-sulfone-PEG8-NHS ester is a bis-alkylating labeling reagent that selectively targets cysteine sulfur atoms from native disulfides. It facilitates bis-alkylation by conjugating thiols derived from the two cysteine residues of a reduced native disulfide bond, such as those present in interchain disulfide bonds of antibodies. This reaction covalently rebridges disulfide bonds via a three-carbon bridge, preserving protein structure. The hydrophilic PEG spacer enhances solubility in aqueous solutions, making it suitable for various biochemical assays and labeling applications.
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