Fig. 1 · Structure
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Bisaramil hydrochloride
Antiarrhythmic Agent
Bisaramil hydrochloride is an antiarrhythmic agent that primarily targets sodium channels to inhibit free radical generation. This compound effectively blocks sodium currents and modulates calcium action potentials in cardiomyocytes following isoproterenol exposure. It has demonstrated the ability to decrease heart rate and prolong electrocardiographic intervals (PR, QRS, and QT), while also reducing cardiac conduction velocity and enhancing the effective refractory period. Additionally, Bisaramil hydrochloride is capable of mitigating ventricular arrhythmias and preventing mortality associated with ventricular fibrillation in ischemic rat models, making it a valuable tool for cardiac research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 96480-44-3 |
| Applications | Antiarrhythmic Agent |
| Formula | C17H24Cl2N2O2 |
| Molecular Weight | 359.29 |
| SMILES | O=C(C1=CC=C(Cl)C=C1)O[C@]2([C@H]3CN(CC)C[C@@H]2CN(C)C3)[H].Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.