Fig. 1 · Structure
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bisSP1
ADCs Linker
bisSP1 is a click chemistry reagent designed for use as a linker in antibody-drug conjugates (ADCs). This compound features an azide group allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, bisSP1 can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) derivatives. Its versatility makes it a valuable tool for the development and optimization of ADCs in chemical biology research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2253947-15-6 |
| Applications | ADCs Linker |
| Formula | C12H23N9O2 |
| Molecular Weight | 325.37 |
| SMILES | [N-]=[N+]=NCCC(N[C@@H](CCCCN)C(NCCCN=[N+]=[N-])=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.