Fig. 1 · Structure
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Bivamelagon
MC4R Agonist
Bivamelagon is a selective agonist of the melanocortin 4 receptor (MC4R) with an EC50 of 0.562 nM in a luciferase assay and 36.5 nM in a cAMP assay, demonstrating its potent activity. This compound exhibits a Ki value of 65 nM, indicating strong binding affinity to its target. Bivamelagon is valuable for research into metabolic disorders, particularly in the context of obesity and diabetes, providing insights into potential therapeutic applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 2641595-54-0 |
| Applications | MC4R Agonist |
| Formula | C35H53ClN4O4 |
| Molecular Weight | 629.27 |
| Synonyms | MC-4R Agonist 2 |
| SMILES | O=C([C@H]1[C@H](C2=CC=C(C=C2)Cl)CN(C1)C(C)(C)C)N3[C@@H](C[C@@H](C3)N([C@@H]4CC[C@@H](CC4)C)C(C(C)C)=O)C(N5CCOCC5)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.