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BL20-MMAE

Catalog No.: A41753
ROR1 ADC Intermediate
BL20-MMAE is an antibody-drug conjugate designed to target the receptor tyrosine kinase ROR1. This compound is synthesized by linking an anti-ROR1 antibody with the cytotoxic agent MMAE through a BL20 linker, facilitating targeted delivery of the drug. BL20-MMAE is primarily utilized in research applications focused on cancer therapeutics, particularly in studies involving ROR1-positive malignancies.
BL20-MMAE 2765612-38-0 ROR1 ADC Intermediate
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionBL20-MMAE is an antibody-drug conjugate designed to target the receptor tyrosine kinase ROR1. This compound is synthesized by linking an anti-ROR1 antibody with the cytotoxic agent MMAE through a BL20 linker, facilitating targeted delivery of the drug. BL20-MMAE is primarily utilized in research applications focused on cancer therapeutics, particularly in studies involving ROR1-positive malignancies.
Product Information
Catalog NumA41753
FormulaC98H133F2N13O23S2
Molecular Weight1963.30
CAS Number2765612-38-0
SMILESO=C(N1CCOCC1)C(C=C2)=CC=C2SC(C(N(C3=CC(F)=C(C(F)=C3)OCCOCCOCCOCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC4=CC=C(C=C4)COC(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(N5[C@](CCC5)([H])[C@H](OC)[C@@H](C)C(N[C@H](C)[C@H](C6=CC=CC=C6)O)=O)=O)=O)=O)=O)=O)=O)=O)C7=O)=O)=C7SC8=CC=C(C=C8)C(N9CCOCC9)=O
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Endocrinology-Hormones > ROR