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Biological Activity
BMS-1166 hydrochloride is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 14.76 mL | 73.79 mL | 147.59 mL |
| 0.5 mM | 2.95 mL | 14.76 mL | 29.52 mL |
| 1 mM | 1.48 mL | 7.38 mL | 14.76 mL |
| 5 mM | 0.3 mL | 1.48 mL | 2.95 mL |
*The above data is based on the productmolecular weight 677.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21481 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 2113650-05-6 |
| Formula | C36H34Cl2N2O7 |
| M. Wt | 677.57 |
| Purity | >98% |
| Synonyms | BMS 1166 Hydrochloride; BMS1166 Hydrochloride; BMS-1166 HCl; BMS 1166 HCl; BMS1166 HCl |
| SMILES | O=C(O)[[email protected]@H]1N(CC2=CC(Cl)=C(OCC3=CC=CC(C4=CC=C(OCCO5)C5=C4)=C3C)C=C2OCC6=CC=CC(C#N)=C6)C[[email protected]](O)C1.Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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Contact information
United StatesAdooq Bioscience
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