BMS-1166 hydrochloride

Catalog No.: A21481

PD-1/PD-L1 interaction inhibitor

BMS-1166 hydrochloride

BMS-1166 hydrochloride Chemical Structure

CAS NO. 2113650-05-6

BMS-1166 hydrochloride is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation.

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5 mg

Regular Price: $495.00

Special Price $396.00

10 mg

Regular Price: $853.00

Special Price $682.40

50 mg

Regular Price: $2,530.00

Special Price $2,024.00

100 mg

Regular Price: $5,060.00

Special Price $4,048.00

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Biological Activity

BMS-1166 hydrochloride is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 14.76 mL 73.79 mL 147.59 mL
0.5 mM 2.95 mL 14.76 mL 29.52 mL
1 mM 1.48 mL 7.38 mL 14.76 mL
5 mM 0.3 mL 1.48 mL 2.95 mL

*The above data is based on the productmolecular weight 677.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A21481
Actions Inhibitor
CAS No. 2113650-05-6
Formula C36H34Cl2N2O7
M. Wt 677.57
Purity >98%
Synonyms BMS 1166 Hydrochloride; BMS1166 Hydrochloride; BMS-1166 HCl; BMS 1166 HCl; BMS1166 HCl
SMILES O=C(O)[[email protected]@H]1N(CC2=CC(Cl)=C(OCC3=CC=CC(C4=CC=C(OCCO5)C5=C4)=C3C)C=C2OCC6=CC=CC(C#N)=C6)C[[email protected]](O)C1.Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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