Fig. 1 · Structure
Documents & Downloads
BMS-337197
IMPDH Inhibitor
BMS-337197 is an inhibitor of inosine monophosphate dehydrogenase (IMPDH), a key enzyme in the de novo synthesis pathway of purine nucleotides. This compound exhibits significant biological activity by effectively reducing guanosine triphosphate (GTP) levels, thereby impacting cellular proliferation and immune response. BMS-337197 is utilized in research applications related to cancer therapy, autoimmune diseases, and viral infections, providing insight into purine metabolism and its implications in various pathologies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 267645-83-0 |
| Applications | IMPDH Inhibitor |
| Formula | C26H27N5O5 |
| Molecular Weight | 489.52 |
| SMILES | O=C(N(C1=CC=CC=C1C2=CN=C(NC3=CC=C(C4=CN=CO4)C(OC)=C3)O2)C)CN5CCOCC5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.