Fig. 1 · Structure
Documents & Downloads
BMS-566419
IMPDH Inhibitor
BMS-566419 is a potent inhibitor of inosine monophosphate dehydrogenase (IMPDH), demonstrating an IC50 value of 91 nM for human IMPDH I and 68 nM for human IMPDH II. This compound exhibits significant anti-inflammatory effects by reducing the expression of MCP-1 and TGF-β1, while also inhibiting antibody production. BMS-566419 is valuable for research applications related to renal fibrosis and organ transplantation, particularly in the context of heart transplant rejection.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 566161-24-8 |
| Applications | IMPDH Inhibitor |
| Formula | C28H30FN5O2 |
| Molecular Weight | 487.57 |
| SMILES | O=C1C2=CC(F)=C(C(NC(C)(C3=CN=C(N4CCN(CC)CC4)C=C3)C)=O)C=C2NC5=CC=CC=C15 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.