Fig. 1 · Structure
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BMS-986224
APJ Receptor Agonist
BMS-986224 is a potent and selective agonist of the APJ receptor, demonstrating a Kd of 0.3 nM. This compound mimics the binding and signaling properties of (Pyr1) apelin-13. BMS-986224 is primarily utilized in research investigating heart failure and related cardiovascular conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 2055200-88-7 |
| Applications | APJ Receptor Agonist |
| Formula | C24H23ClN4O6 |
| Molecular Weight | 498.92 |
| SMILES | O=C1NC(COCC)=C(C2=C(OC)C=CC=C2OC)C(O)=C1C3=NN=C(CC4=NC=C(C=C4)Cl)O3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.