Fig. 1 · Structure
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BMY 14802
σ1R Antagonist
BMY 14802 is a selective sigma-1 receptor (σ1R) antagonist that also exhibits agonistic activity at serotonin (5-HT) 1A and adrenergic alpha-1 receptors. This compound has demonstrated the capability to inhibit abnormal involuntary movements (AIM) in rat models of Parkinson's disease, suggesting its potential in modulating motor symptoms associated with this condition. BMY 14802 serves as a valuable tool for research in neuropharmacology and the study of movement disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 105565-56-8 |
| Applications | σ1R Antagonist |
| Formula | C18H22F2N4O |
| Molecular Weight | 348.39 |
| SMILES | FC1=CN=C(N2CCN(CCCC(C3=CC=C(C=C3)F)O)CC2)N=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.