Boc-Aminooxy-PEG1-azide is a PEG-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). Featuring an azide group, it participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules and can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-functionalized compounds. This reagent is pivotal for studies in targeted protein degradation, providing a versatile tool for advancing research in cell biology and therapeutic development.
Boc-Aminooxy-PEG1-azide is a PEG-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). Featuring an azide group, it participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules and can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-functionalized compounds. This reagent is pivotal for studies in targeted protein degradation, providing a versatile tool for advancing research in cell biology and therapeutic development.
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