Boc-Gly-Gly-Phe-Gly-OH TFA

Catalog No.: A43159
ADC Linker
Boc-Gly-Gly-Phe-Gly-OH TFA is a protease-cleavable linker designed for use in antibody-drug conjugates (ADCs). This self-assembling tetrapeptide features N- and C-terminal protection, facilitating targeted drug delivery. Its key biological activity includes enabling specific cleavage by proteases, thus enhancing the release of therapeutic agents in the desired cellular environment. This reagent is essential for researchers developing innovative ADC platforms in cancer therapy.
Grouped product items
Size Price Stock Qty
5mg
$20.00
In stock
10mg
$35.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionBoc-Gly-Gly-Phe-Gly-OH TFA is a protease-cleavable linker designed for use in antibody-drug conjugates (ADCs). This self-assembling tetrapeptide features N- and C-terminal protection, facilitating targeted drug delivery. Its key biological activity includes enabling specific cleavage by proteases, thus enhancing the release of therapeutic agents in the desired cellular environment. This reagent is essential for researchers developing innovative ADC platforms in cancer therapy.
Product Information
Catalog NumA43159
FormulaC22H29F3N4O9
Molecular Weight550.48
CAS Number2450273-39-7
Sequence shorteningBoc-GGFG
SMILESC(C(O)=O)(F)(F)F.[C@@H](CC1=CC=CC=C1)(NC(CNC(CNC(OC(C)(C)C)=O)=O)=O)C(NCC(O)=O)=O
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This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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