Fig. 1 · Structure
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Boc-NH-PEG2-CH2COOH
PROTAC Linker
Boc-NH-PEG2-CH2COOH is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the connection between a target protein and an E3 ligase, promoting ubiquitination and subsequent proteasomal degradation of the target. Its hydrophilic PEG structure enhances solubility and biocompatibility, making it suitable for various drug discovery and development applications within targeted protein degradation research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 108466-89-3 |
| Applications | PROTAC Linker |
| Formula | C11H21NO6 |
| Molecular Weight | 263.29 |
| SMILES | CC(C)(C)OC(NCCOCCOCC(O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.