Boc-PEG2-Val-Cit-PAB-OH is an enzyme-cleavable linker designed for antibody-drug conjugates (ADCs). The compound features a Boc-protected amine, a flexible PEG spacer, and a Val-Cit-PAB dipeptide, facilitating targeted delivery. The benzylic alcohol on the PAB moiety allows for the attachment of reactive groups for conjugation with drug payloads. Upon exposure to acidic conditions, the Boc group is removed to yield a primary amine for subsequent coupling reactions. The Val-Cit-PAB component is readily cleaved by cellular proteases, enabling the efficient release of therapeutic agents within target cells.
Boc-PEG2-Val-Cit-PAB-OH is an enzyme-cleavable linker designed for antibody-drug conjugates (ADCs). The compound features a Boc-protected amine, a flexible PEG spacer, and a Val-Cit-PAB dipeptide, facilitating targeted delivery. The benzylic alcohol on the PAB moiety allows for the attachment of reactive groups for conjugation with drug payloads. Upon exposure to acidic conditions, the Boc group is removed to yield a primary amine for subsequent coupling reactions. The Val-Cit-PAB component is readily cleaved by cellular proteases, enabling the efficient release of therapeutic agents within target cells.
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