Boc-PEG4-Val-Cit-PAB-OH is an enzyme-cleavable linker designed for antibody-drug conjugates (ADCs). This compound features a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide, facilitating the attachment of drug payloads through reactive groups such as PNP. The Boc group can be removed via acidic treatment, yielding a primary amine suitable for forming amides through coupling reactions. The Val-Cit-PAB component is preferentially cleaved by cellular proteases, enabling efficient release of the cytotoxic payload within targeted cells.
Boc-PEG4-Val-Cit-PAB-OH is an enzyme-cleavable linker designed for antibody-drug conjugates (ADCs). This compound features a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide, facilitating the attachment of drug payloads through reactive groups such as PNP. The Boc group can be removed via acidic treatment, yielding a primary amine suitable for forming amides through coupling reactions. The Val-Cit-PAB component is preferentially cleaved by cellular proteases, enabling efficient release of the cytotoxic payload within targeted cells.
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