Fig. 1 · Structure
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Bofutrelvir
Mpro Inhibitor
Bofutrelvir is an inhibitor of the SARS-CoV-2 main protease (Mpro), demonstrating an IC50 value of 53 nM and an EC50 of 0.53 μM. This compound exhibits significant antiviral activity against various SARS-CoV-2 variants, with EC50 values ranging from 0.26 to 0.42 μM. Additionally, Bofutrelvir shows an additive antiviral effect when used in conjunction with Remdesivir, making it a valuable reagent for research into COVID-19 treatment strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2103278-86-8 |
| Applications | Mpro Inhibitor |
| Formula | C25H32N4O4 |
| Molecular Weight | 452.55 |
| Synonyms | FB2001 |
| SMILES | O=C(C(N1)=CC2=C1C=CC=C2)N[C@@H](CC3CCCCC3)C(N[C@H](C=O)C[C@H]4C(NCC4)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.