Fig. 1 · Structure
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Br-C3-methyl ester
PROTAC Linker
Br-C3-methyl ester is an alkyl/ether-based PROTAC linker designed for targeted protein degradation applications. This compound facilitates the synthesis of PROTAC PD-1/PD-L1 degrader-1, enabling the selective degradation of PD-1, which is crucial for cancer immunotherapy research. Its use can aid in elucidating the role of PD-1 in immune regulation and potentially contribute to the development of novel therapeutic strategies against cancer.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 4897-84-1 |
| Applications | PROTAC Linker |
| Formula | C5H9BrO2 |
| Molecular Weight | 181.03 |
| SMILES | COC(CCCBr)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.