BRD4 Inhibitor-40 primarily targets the bromodomain protein BRD4, inhibiting its binding domains BRD4-BD1 and BRD4-BD2 with IC50 values of 16.1 nM and 142.18 nM, respectively. This compound effectively modulates the expression of c-Myc and p21, resulting in G1 phase cell cycle arrest. Additionally, BRD4 Inhibitor-40 has demonstrated efficacy in inhibiting Pkd1-null renal cystic epithelial cells and blocking renal cyst formation in both Madin-Darby canine kidney and embryonic kidney vesicle models, thus showcasing its potential in renal research applications.
BRD4 Inhibitor-40 primarily targets the bromodomain protein BRD4, inhibiting its binding domains BRD4-BD1 and BRD4-BD2 with IC50 values of 16.1 nM and 142.18 nM, respectively. This compound effectively modulates the expression of c-Myc and p21, resulting in G1 phase cell cycle arrest. Additionally, BRD4 Inhibitor-40 has demonstrated efficacy in inhibiting Pkd1-null renal cystic epithelial cells and blocking renal cyst formation in both Madin-Darby canine kidney and embryonic kidney vesicle models, thus showcasing its potential in renal research applications.
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