BRD4-IN-5

Catalog No.: A40524
BRD4 Inhibitor
BRD4-IN-5 is a selective inhibitor of the bromodomain protein BRD4. It demonstrates notable activity with Ki values of 9.7 nM for the first bromodomain (BDI) and 16.1 nM for the second bromodomain (BDII). This compound is valuable for use in cancer research, particularly in studies exploring the role of BRD4 in oncogenic transcriptional regulation and therapeutic interventions.
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5mg
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50mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionBRD4-IN-5 is a selective inhibitor of the bromodomain protein BRD4. It demonstrates notable activity with Ki values of 9.7 nM for the first bromodomain (BDI) and 16.1 nM for the second bromodomain (BDII). This compound is valuable for use in cancer research, particularly in studies exploring the role of BRD4 in oncogenic transcriptional regulation and therapeutic interventions.
Product Information
Catalog NumA40524
FormulaC25H21F2N3O4
Molecular Weight465.45
CAS Number1445993-41-8
SMILESCN1C=C(C2=C(OC3=C(F)C=C(F)C=C3)C=CC(C(NC4CCOC4)=O)=C2)C5=C(NC=C5)C1=O
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