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BS148

Sigma-2 Receptor Agonist

BS148 is a selective agonist for the sigma-2 receptor (S2R) with a binding affinity (Ki) of 20 nM and shows over 80-fold selectivity for S2R compared to S1R. This compound activates the endoplasmic reticulum stress response by upregulating key genes such as protein kinase R-like ER kinase (PERK), activating transcription factor 4 (ATF4), and C/EBP homologous protein (CHOP), leading to apoptosis in melanoma cells. Additionally, BS148 downregulates cholesterol-related genes and activates the MAPK signaling pathway, making it a valuable tool for melanoma research.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Agonist
CAS Number	2162116-09-6
Applications	Sigma-2 Receptor Agonist
Formula	C₂₁H₃₁NS₂
Molecular Weight	361.61
SMILES	N1(CC2SC3(CCCCC3)SC2)CCC(CC4=CC=CC=C4)CC1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.